Sabin and Riskind Respond

Florence R. Sabin, 1915

Florence Rena Sabin (1871-1953)

Florence Rena Sabin [5] had successful careers as both a researcher and public health reformer. When Johns Hopkins University [6] Medical School opened, accepting women and men on the same basis, Sabin was one of the first to enter. After the successful completion of her MD degree, Sabin went on to become the first female faculty member and later full-time professor at Johns Hopkins. From 1924?...

A multivariate Powell-Sabin interpolant

We consider the problem of constructing a C1 piecewise quadratic interpolant, Q, to positional and gradient data defined at the vertices of a tessellation of n-simplices in IR. The key to the interpolation scheme is to appropriately subdivide each simplex to ensure that certain necessary geometric constraints are satisfied by the subdivision points. We establish these constraints using the Bern...

Sabin Vaccine Reversion in the Field: a Comprehensive Analysis of Sabin-Like Poliovirus Isolates in Nigeria.

UNLABELLED To assess the dynamics of genetic reversion of live poliovirus vaccine in humans, we studied molecular evolution in Sabin-like poliovirus isolates from Nigerian acute flaccid paralysis cases obtained from routine surveillance. We employed a novel modeling approach to infer substitution and recombination rates from whole-genome sequences and information about poliovirus infection dyna...

Complete genomic characterization of an intertypic Sabin 3/Sabin 2 capsid recombinant.

The genetic properties of strain K/2002, isolated from fecal samples of a 7-month-old child who had received his first oral poliovirus vaccine (OPV) dose at the age of 3 months, are described. Preliminary sequencing characterization of isolate K/2002 revealed an S3/S2 recombination event at the 3' end of the VP1 coding region. A recombination event resulted in the introduction of six Sabin 2 am...